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Loneliness Linked With Elevated Risk of Cardiovascular Disease in Patients With Diabetes

07/05/2023

Sophia Antipolis: Loneliness is a bigger risk factor for heart disease in patients with diabetes than diet, exercise, smoking and depression, according to research published today in European Heart Journal, a journal of the European Society of Cardiology (ESC).¹

“The quality of social contact appears to be more important for heart health in people with diabetes than the number of engagements,” said study author Professor Lu Qi of Tulane University School of Public Health and Tropical Medicine, New Orleans, US. “We should not downplay the important of loneliness on physical and emotional health. I would encourage patients with diabetes who feel lonely to join a group or class and try to make friends with people who have shared interests.”

“Loneliness and social isolation are common in today's societies and have become a research focus during the last years, especially driven by the COVID-19 pandemic and the continuous digitalisation of society,”² state Kahl et al. in an accompanying editorial. Loneliness refers to the quality of social contacts, while isolation refers to the quantity. They add: “The human species is inherently social by nature. Humans not only require the presence of others, but rely on meaningful social relationship[s] to develop into healthy adulthood. As individuals, we strive to belong to a family, a peer group, a community. These social interactions with family, friends, neighbours or colleagues are paramount for our physical and mental well-being.”

Patients with diabetes are at greater risk of cardiovascular disease and are more likely to be lonely than their healthy peers.^3,4 Previous studies in the general population have found that loneliness and social isolation are both related to a higher likelihood of cardiovascular disease.⁵ This study in patients with diabetes examined whether patients who were lonely or socially isolated were more likely to develop cardiovascular disease than those who were not.

The study included 18,509 adults aged 37 to 73 years in the UK Biobank with diabetes but no cardiovascular disease at baseline.⁶ Loneliness and isolation were assessed with questionnaires, with high-risk features allocated one point each. High-risk loneliness feature were feeling lonely and never or almost never being able to confide in someone, for a total score of 0 to 2. High-risk social isolation factors were living alone, having friends and family visit less than once a month, and not participating in social activity at least once per week, for a total score of 0 to 3.

Some 61.1%, 29.6% and 9.3% participants had loneliness scores of 0, 1 or 2, respectively, while 44.9%, 41.9% and 13.2% had isolation scores of 0, 1 or >2, respectively. The researchers analysed the association between loneliness, isolation and incident cardiovascular disease after adjusting for factors that could influence the relationships including sex, age, deprivation, body mass index (BMI), medications, physical activity, diet, alcohol, smoking and control of blood sugar, blood pressure and cholesterol.

During an average follow-up of 10.7 years, 3,247 participants developed cardiovascular disease, of which 2,771 was coronary heart disease and 701 was stroke (some patients had both). Compared to participants with the lowest loneliness score, the risk of cardiovascular disease was 11% and 26% higher in those with scores of 1 or 2, respectively. Similar results were observed for coronary heart disease but the association with stroke was not significant. Social isolation scores were not significantly related to any of the cardiovascular outcomes.

The researchers also assessed the relative importance of loneliness, compared with other risk factors, on the incidence of cardiovascular disease. Loneliness showed a weaker influence than kidney function, cholesterol and BMI, but a stronger influence than depression, smoking, physical activity and diet.

Professor Qi said: “Loneliness ranked higher as a predisposing factor for cardiovascular disease than several lifestyle habits. We also found that for patients with diabetes, the consequence of physical risk factors (i.e. poorly controlled blood sugar, high blood pressure, high cholesterol, smoking and poor kidney function) was greater in those who were lonely compared to those who were not.”

He concluded: “The findings suggest that asking patients with diabetes about loneliness should become part of standard assessment, with referral of those affected to mental health services.”

Funding: The study was supported by grants from the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), and the National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383, DK078616).

Disclosures: The authors declare no conflicts of interest.

References
¹Wang X, Ma H, Li X, et al. Joint association of loneliness and traditional risk factor control and incident cardiovascular disease in diabetes patients. Eur Heart J. 2023. doi:10.1093/eurheartj/ehad306.
Link will go live on publication:
https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehad306
²Kahl KG, Stapel B, Heitland I. A lonely heart is a broken heart: it is time for a biopsychosocial cardiovascular disease model. Eur Heart J. 2023. doi:10.1093/eurheartj/ehad310.
Link will go live on publication:
https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehad310
³Shah AD, Langenberg C, Rapsomaniki E, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015;3:105–113.
⁴Petitte T, Mallow J, Barnes E, et al. A systematic review of loneliness and common chronic physical conditions in adults. Open Psychol J. 2015;8:113–132.
⁵Christiansen J, Lund R, Qualter P, et al. Loneliness, social isolation, and chronic disease outcomes. Ann Behav Med. 2021;55:203–215.
⁶UK Biobank is a large-scale biomedical database and research resource containing anonymised genetic, lifestyle and health information from half a million UK participants.

About the European Society of Cardiology
The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.

About European Heart Journal
European Heart Journal (EHJ) is the flagship journal of the European Society of Cardiology. It is the world’s leading publication in general cardiology. Please acknowledge the journal as a source in any articles.